IGF-1 LR3 - Research Grade

10 vials x 0.1 mg (1 mg total)

$35.00

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1)

Informative Description: IGF-1 LR3 is a highly potent synthetic analog of human Insulin-like Growth Factor-1 (IGF-1). It has been structurally modified by substituting glutamic acid with arginine at position 3 (R3) and adding a 13-amino-acid peptide extension at its N-terminus (Long). This chemical alteration drastically reduces its affinity for IGF-binding proteins (IGFBPs), which significantly increases its plasma half-life to approximately 20–30 hours, compared to the brief 20-minute half-life of the standard native version.
Molecular Function:
Prolonged IGF-1 Receptor Activation: By evading binding proteins, a massive amount of the peptide remains free and biologically active to bind to cellular receptors, maximizing downstream intracellular signaling.
Akt/mTOR Pathway Stimulation: Potently triggers the Akt/mTOR signaling cascade, the primary cellular mechanism responsible for driving protein synthesis, nitrogen retention, and overall cellular growth.
Induction of Cellular Hyperplasia: Unlike other compounds that only increase the size of existing cells (hypertrophy), IGF-1 LR3 promotes the proliferation and differentiation of satellite cells, leading to the formation of entirely new muscle fibers.
Primary Uses (Research Applications):
Extreme Muscle Growth & Regeneration Studies: Extensively researched in laboratory settings to analyze the development of lean muscle tissue and evaluate accelerated recovery from severe muscle tears or dystrophies.
Insulin Sensitivity & Nutrient Transport Research: Utilized in metabolic models to study the optimized shuttling of glucose and amino acids directly into muscle cells, effectively diverting nutrients away from adipose storage.
Bone Density & Cartilage Regeneration Models: Evaluated in scientific protocols for its ability to stimulate the proliferation of chondrocytes and osteoblasts, which are essential for the structural repair of joints and osseous tissue.